https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22674 in-situ occlusive thrombus formation (Folt’s model of ‘physiological’ thrombus). Intravenous tPA was administered 60 minutes post-occlusion (n = 6-7/group). Sustained recanalization rates were 0%, 17%, 67% and 71%, for 0.9, 1.8, 4.5, and 10 mg/kg, respectively. Median time to sustained recanalization onset decreased with increasing dosage. We conclude that 10 mg/kg of tPA is too effective, whereas 0.9 mg/kg is ineffective for lysis of occlusive thrombi formed in situ. Neither dose mimics clinical tPA responses. A dose of 2x the clinical dose is a more appropriate mimic of clinical tPA recanalization in this model.]]> Wed 11 Apr 2018 16:44:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16387 Wed 11 Apr 2018 16:12:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16985 Wed 11 Apr 2018 15:07:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24819 0.1). Conclusions: Microbubble-enhanced sonothrombolysis improves microvascular patency. This effect is not dose- or microbubble formulation-dependent suggesting a class effect of microbubbles promoting microvascular reopening. This study demonstrates that microbubble-enhanced sonothrombolysis may be a therapeutic strategy for patients with persistent hypoperfusion of the ischemic territory.]]> Wed 09 Mar 2022 16:00:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16806 Tue 24 Aug 2021 14:40:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29067 P<0.0001). Recanalization rates were not significantly higher with additional ultrasound in either model. Conclusion: In this model, the degree of carotid stenosis had a large effect on thrombolytic recanalization. Sonothrombolysis using standard parameters for intracranial sonothrombolysis did not increase recanalization. Further testing is warranted. The degree of underlying stenosis may be an important predictor of thrombolytic recanalization, and clinical correlation of these findings may provide new approaches to treatment selection for patients with carotid occlusion.]]> Fri 01 Apr 2022 09:24:48 AEDT ]]>